In the News

Use of low-dose methotrexate is associated with small to moderate elevations in risks for skin cancer and gastrointestinal, infectious, pulmonary, and haematologic adverse events, according to a study published in the Annals of Internal Medicine.

Methotrexate is the most commonly...

Amlodipine lowered long-term gout risk, compared with lisinopril or chlorthalidone, in older adults with hypertension, according to a study published in the Journal of Hypertension.

“Our study is clinically relevant as the prevalence of gout has been rising in the United States and...

Researchers have identified the cause of a mysterious illness that has affected 3 families over the past 20 years, and have termed the new disease Cleavage-Resistant RIPK1-Induced Autoinflammatory (CRIA) Syndrome.

Daniel Kastner, MD, National Human Genome Research Institute (NHGRI), part...

Heart disease is an independent risk factor for severe adverse skin reactions in patients taking allopurinol for gout, according to a study published in CMAJ.

A previous study found an association between heart disease and increased risk of hospitalisation for allopurinol-related...

The US Food and Drug Administration (FDA) has approved rituximab (Rituxan) injection to treat granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in children aged ≥2 years in combination with glucocorticoids.

This is the first approved treatment for children with...

Four modifiable risk factors could individually account for a notable proportion of hyperuricemia cases, according to a study published in Arthritis & Rheumatology.

For the study, Hyon K. Choi, MD, Massachusetts General Hospital, Boston, Massachusetts, and colleagues used data...

Combining methotrexate with a tumour necrosis factor (TNF) biologic or non-TNF biologics reduce disease activity and improves remission when compared with methotrexate alone, according to a study published in the Journal of General Internal Medicine.

For the study, Katrina E....

The American College of Rheumatology (ACR), in partnership with the Spondylitis Association of America (SAA) and the Spondyloarthritis Research and Treatment Network (SPARTAN), released updated recommendations for the treatment of ankylosing spondylitis (AS) and non-radiographic axial...

A study of patients with active rheumatoid arthritis (RA) who had an inadequate response or intolerance to 1 or more biologic disease-modifying antirheumatic drugs (DMARDs), clinical response was achieved at week 12 by a significantly greater proportion of patients treated with filgotinib...

Oral steroid use in patients with the inflammatory diseases polymyalgia rheumatica and/or giant cell arteritis significantly increased the risk of infection, and the risk increased with higher doses, according to a study published in CMAJ (Canadian Medical Association Journal).

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